1.1.1 Pharmacokinetics and Toxicokinetics
  • 1.1.1.1 Bioavailability and Absorption
  • 1.1.1.2 Distribution
  • 1.1.1.3 Metabolism
  • 1.1.1.4 Elimination
  • 1.1.1.5 Clearance
  • 1.1.1.6 Models (eg, compartmental, physiologic)
1.1.2 Pharmacodynamics and Toxicodynamics
  • 1.1.2.1 Dose/Concentration Relationship to Effect
  • 1.1.2.2 Structure-Activity Relationship
  • 1.1.2.3 Receptor Agonism/Antagonism
  • 1.1.2.4 Receptor Regulation
1.1.3 Adverse Effects
  • 1.1.3.1 Mechanistic (predictable)
  • 1.1.3.2 Idiosyncratic
1.1.4 Interactions
  • 1.1.4.1 Xenobiotic-Environment
  • 1.1.4.2 Xenobiotic-Food
  • 1.1.4.3 Xenobiotic-Xenobiotic (eg, drug-drug)
1.1.5 Proteomics
1.1.6 Tolerance and Withdrawal
  • 1.1.6.1 Behavioral Tolerance
  • 1.1.6.2 Biologic Tolerance
1.1.7 Immunologic Response (eg, antibodies, cytokines)
1.1.8 Pharmacogenomics and Toxicogenomics (eg, xenobiotic response, gene expression profiling)