Pharmacokinetics in toxicological practice


The aim of this module is to revisit some of the basic pharmacokinetic concepts described in section 1 by looking at their influence in two specific poisonings (Paracetamol/Acetaminpohen and Lithium).
In doing so your will be effectively learning how to manage paracetamol and lithium. This requires an understanding of hepatic metabolism and renal elimination.
In subsequent modules related to specific toxins your should consider the kinetics and dynamics in each case


There are specific readings in each of the activity sections for paracetamol and lithium



Do the problems and reading in both of these sections

Optional Exercise

Undertake the self-test section: ‘A mystery of interaction’ section of HyperTox (download HyperTox from