Link to [[3.2.1.1.1 Acidosis Teaching Resources]]
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==ACIDOSIS==

There are only a few toxins that directly cause acidosis
* [[2.1.11.5.1 Acute Management of Alcohol Problems|alcohol]]
* [[2.2.5.2.5 Methanol|methanol]]
* paraldehyde
* isoniazid (lactic acid)
* [[2.2.5.2.2 Ethylene glycol|ethylene glycol]]
* [[2.1.1.4 Salicylates|salicylates]]
* [[Glyphosate|glyphosate]]

However
* renal failure (GFR < 10% of normal)
* lactic acidosis

may occur secondary to tissue hypoxia, shock or seizures from poisoning with many toxins including
* [[3.2.1.1.9 Differential Diagnosis of Sympathomimetic Syndrome|Sympathomimetic drugs]]
* [[2.2.9.1.1 Carbon monoxide|Carbon monoxide]]
* [[2.1.11.9.2.1 Tricyclic Antidepressants|Tricyclic antidepressants]]
* Cellular poisons (e.g. [[2.1.1.5.1 Colchicine|colchicine]], [[2.1.9.6 Iron|iron]])

Drug toxicity worsened by acidosis:
* Tricyclic antidepressants
* [[3.4.3.4 Antiarrhythmics|Antiarrhythmic drugs]]
* Quinidine

Features that help to differentiate between these drugs are
* [[Level of Consciousness|LEVEL OF CONSCIOUSNESS]]
* [[Myoclonic jerking or Hyperreflexia|HYPERREFLEXIA]]
* [[Heart rates|HEART RATE]]
* [[ECG Changes|ECG CHANGES]]
* [[Electrolytes & Blood Glucose|ELECTROLYTES/BLOOD GLUCOSE]]
* [[Osmolal Gap|OSMOLAL GAP]]
* [[Blood Concentrations|BLOOD CONCENTRATIONS]]