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Sunday, November 12

  1. user_add jacmap jacmap joined WikiTox
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Thursday, October 12

  1. page Clonidine edited ... There has been considerable controversy over the use naloxone in clonidine overdose. Clonidine…
    ...
    There has been considerable controversy over the use naloxone in clonidine overdose. Clonidine's inhibition of central sympathetic outflow may be mediated by endogenous opioid release and this is the postulated reason for the effect of naloxone in clonidine overdose. There is variable effectiveness of naloxone in many different studies, with significant dose variations between the studies.
    The greatest effect appears to be with reversal of CNS depression, with less effect on cardiovascular and respiratory depression. A trial of naloxone can certainly be justified, particularly in paediatric patients as a temporising measure if definitive airway protection (endotracheal intubation) cannot be provided.
    ...
    opioid withdrawal.
    Adults: 0.4-4 mg IV in adults, and if effective it may be continued as an infusion.
    Paediatric: 0.4 mg IV, repeated as required (the risk
    Reports of opioid withdrawal is minimal in paediatric patients)patients who respond have been with doses of 0.15 mg/kg
    Other agents
    Yohimbine
    (view changes)
    4:25 pm
  2. page 2.1.11.9.2.4.1 Bupropion edited ... Cardiac effects ECG changes have been reported after ingestions over 1.5 g.(12;17) Cardiac ar…
    ...
    Cardiac effects
    ECG changes have been reported after ingestions over 1.5 g.(12;17) Cardiac arrest has been reported to closely follow seizures.(14) Broad complex tachycardia and cardiac arrest in hospital have also been observed.(15;16)
    These ECG changes including QRS widening appear to be due to blockage of intracellular gap junctions. Correction of acidosis may restore gap junction function and therefore intracellular communication.
    INVESTIGATIONS
    ECG
    (view changes)
    9:40 am

Sunday, October 8

  1. 11:00 am
  2. user_add Indiram Indiram joined WikiTox
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Sunday, September 3

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